Yale University
Department of Statistics
Seminar list for 1996-97 
A Model for Cancer Trends by Histologic Type Incorporating Uncertain
Diagnoses
Monday, September 9, 1996
Keqin Qi
Ph.D. Candidate
Department of Biostatistics
Yale University
Seminar to be held in Room 309, LEPH, 60 College Street
When the time trends of male lung cancer in Connecticut are studied by
histologic type, a serious problem arises in how to deal with the category
of Not Otherwise Specified (NOS) type because this can account for a high
percentage of the data. In this talk, the NOS cases are assumed as a
mixture of known histologic types. We investigate the time trends of three
temporal effects, i.e. age, period and cohort by employing a technique for
handling missing data. This model depends on a pre-specified set of
allocation probability distributions. Identifiability of
the
time trends are discussed in general. The results are shown at last by
using the EM algorithm and the Markov Chain Monte Carlo (MCMC) sampling
techniques.