Renee Zellweger is Betty, a Kansas waitress who wants to be a nurse, who is infatuated with a soap opera actor (Greg Kinnear), and who is married to Del, a cheating, stupid male chauvinist who's trying to sell some stolen drugs. Unfortunately for him, he gets brutally, bloodily murdered instead, while Betty secretly watches. It leaves her unhinged, believing that Kinnear is really the character he plays, Dr. David Ravell, and that she is his RN ex-fiancée. She heads for LA to find her lost love, not knowing the stolen drugs are in her trunk. Pursuing her are Charlie and Wesley (Morgan Freeman and Chris Rock respectively), the hit men who inadvertently killed Del before they found out where the drugs were hidden. They pursue her across the country, while Charlie gradually falls in love with his image of her.
And in LA, things get totally bizarre, as no one realizes that Betty is delusional. Alternately funny and touching, this movie is almost perfect. Stop reading commentaries and go see it.