In what will probably find itself on my list of Fuller's best movies (that is, once I see more of them that just this and Shock Corridor), Pickup on South Street is a film noir where the femme fatale, as well as the male protagonist, are not the stereotypical ones in the genre. Like most of his other works, Fuller injects his own experiences and the sense of New York style that is usually absent in the Hollywood noirs. On a small budget- at least for the likes of Darryl F. Zanuck- Fuller and his actors create personas that are likable even in such a dark atmosphere. The good guys are basically the ones who won't get violent with you even as they're looking for an extra buck.
Richard Widmark, Jean Peters, and Thelma Ritter are all terrific in the lead parts. Widmark is one only a few actors I can think of who could've really pulled off this character. He's a little like Bugs Bunny, as he can be a wise-ass who is a little sneaky. On the other hand, the character of Skip McCoy does have a set of values in his life. He doesn't go into other people's affairs, and doesn't try and care about much of the working world outside of his little shack on the river, after being sent away for three years. He slips up, unbeknownst to him, when he pickpockets a woman (Peters) on the train, and lifts an item that's under the eye of the Government. It may have some secrets that could make him a lot of money. But at what cost is the centerpiece of the film, as it involves stoolie Moe (Ritter is one of the finest, and most believable, character actors from the period), the woman's ex (a volatile Kiley), and the police department.
Aside from the thematic elements, which are told with a keen dramatic, journalistic style (as was Fuller's previous position, along with boxer), the dialog is fresh and involving. There's a spontaneity in many of Fuller's camera moves. And what a third act. This is a lean, tight film-noir that is worth checking out even if you're not familiar with Fuller (it's comparatively less bizarre than some of his later works).