Not funny, not coherent, not worth watching. The Road to Wellville doesn't make any sort of sense -- it flits back and forth between three equally nonsensical plotlines, and, after about six hours, ends. It does feature a great deal of nudity, but that's hardly an excuse for wasting precious natural resources like John Cusak, Anthony Hopkins, and Dana Carvey.
If you want to see Cusak in a comedy, rent Grosse Point Blank. If you want loads of gratuitous nudity, rent Beach Babes from Beyond. There is no excuse whatsoever for watching this film -- it's time out of my life I can never have back.